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pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can reduce panobinostat amounts by ~70% and lead to therapy failure.pentobarbital will minimize the level or outcome of siponimod by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of o